Search results for: M. Pallotta

Items from 1 to 20 out of 27 results

article

Baricitinib versus tocilizumab in critically ill COVID‐19 patients: A retrospective cohort study

Grace M. Conroy, Seth R. Bauer, Andrea M. Pallotta, Abhijit Duggal, more

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy > 44 > 1 > 28 - 38

Objectives The immunomodulators tocilizumab and baricitinib improve outcomes in severely ill patients with coronavirus disease 2019 (COVID‐19); however, comparative analyses of clinical outcomes related to these agents are lacking. A tocilizumab national shortage shifted treatment to baricitinib in critically ill patients, allowing for an outcome comparison in a similar population. The purpose of...

article

Simplifying ARV Therapy in the Setting of Resistance

Neha Sheth Pandit, Daniel B. Chastain, Andrea M. Pallotta, Melissa E. Badowski, more

Current Infectious Disease Reports > 2019 > 21 > 10 > 1-11

Purpose of Review HIV treatment simplification is typically indicated for virologically suppressed patients with no baseline resistance-associated mutations (RAMs) or prior virologic failure (VF) to the simplification regimen. Simplification can occur to minimize pill burden, toxicities, drug-drug interactions, or costs. As most studies for treatment simplification excluded patients with baseline...

article

Implementation of a Stewardship Initiative on Respiratory Viral PCR‐based Antibiotic Deescalation

Pavithra Srinivas, Kaitlyn R. Rivard, Andrea M. Pallotta, Vasilios Athans, more

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy > 39 > 6 > 709 - 717

Objective Respiratory viral polymerase chain reaction (RV PCR) tests assist in rapidly identifying viral pathogens and differentiating viral versus bacterial causes of pneumonia. Studies evaluating the use of RV PCR tests on antibiotic use in adults have demonstrated mixed results. We implemented an antimicrobial stewardship (ASP) intervention for patients with a positive RV PCR test result who were...

article

Chlorpyrifos exposure affects fgf8, sox9, and bmp4 expression required for cranial neural crest morphogenesis and chondrogenesis in Xenopus laevis embryos

Margherita Tussellino, Raffaele Ronca, Rosa Carotenuto, Maria M. Pallotta, more

Environmental and Molecular Mutagenesis > 57 > 8 > 630 - 640

Chlorpyrifos (CPF) is an organophosphate insecticide used primarily to control foliage and soil‐borne insect pests on a variety of food and feed crops. In mammals, maternal exposure to CPF has been reported to induce dose‐related abnormalities such as slower brain growth and cerebral cortex thinning. In lower vertebrates, for example, fish and amphibians, teratogenic activity of this compound is correlated...

article

Short interspersed DNA elements and miRNAs: a novel hidden gene regulation layer in zebrafish?

Margherita Scarpato, Claudia Angelini, Ennio Cocca, Maria M. Pallotta, more

Chromosome Research > 2015 > 23 > 3 > 533-544

In this study, we investigated by in silico analysis the possible correlation between microRNAs (miRNAs) and Anamnia V-SINEs (a superfamily of short interspersed nuclear elements), which belong to those retroposon families that have been preserved in vertebrate genomes for millions of years and are actively transcribed because they are embedded in the 3′ untranslated region (UTR) of several genes...

article

Construction of a barley bacterial artificial chromosome library suitable for cloning genes for boron tolerance, sodium exclusion and high grain zinc content

B. J. Shi, T. Sutton, N. C. Collins, M. Pallotta, more

Plant Breeding > 129 > 3 > 291 - 296

With 3 figures and 2 tables AbstractTolerance to soil boron toxicity, salinity and zinc deficiency is required for maintaining adequate yields on many soils, while a high content of zinc in the grain is desirable for human nutrition. To facilitate the identification of genes for these traits in barley, we constructed a bacterial artificial chromosome (BAC) library of the barley‐doubled haploid line...

article

Physical analysis of the complex rye (Secale cereale L.) Alt4 aluminium (aluminum) tolerance locus using a whole-genome BAC library of rye cv. Blanco

B.-J. Shi, J. P. Gustafson, J. Button, J. Miyazaki, more

Theoretical and Applied Genetics > 2009 > 119 > 4 > 695-704

Rye is a diploid crop species with many outstanding qualities, and is important as a source of new traits for wheat and triticale improvement. Rye is highly tolerant of aluminum (Al) toxicity, and possesses a complex structure at the Alt4 Al tolerance locus not found at the corresponding locus in wheat. Here we describe a BAC library of rye cv. Blanco, representing a valuable resource for rye molecular...

article

The gas monitoring system for the Resistive Plate Chamber detector of the CMS experiment at LHC

M. Abbrescia, A. Colaleo, R. Guida, G. Iaselli, more

Nuclear Physics B (Proceedings Supplements) > 2008 > 177-178 > Complete > 293-296

Due to its large volume (18 m ³ )the Resistive Plate Chamber (RPC) detector of the Compact Muon Solenoid (CMS) experiment at the LHC proton collider (CERN, Switzerland) will employ a gas re-circulation system. Since the mixture composition and quality are crucial issues for the detector operation, CMS-RPC will use an online gas analysis and monitoring system. An overview of both the CMS-RPC...

article

Correlated Λd pairs from the Kstop−A→ΛdA′ reaction

M. Agnello, G. Beer, L. Benussi, M. Bertani, more

Physics Letters B > 2007 > 654 > 3-4 > 80-86

Correlated Λd pairs emitted after the absorption of negative kaons at rest Kstop−A→ΛdA′ in light nuclei ⁶ Li and ¹² C are studied. Λ-hyperons and deuterons are found to be preferentially emitted in opposite directions. The Λd invariant mass spectrum of ⁶ Li shows a bump whose mass is 3251±6 MeV/c2. The bump mass (binding energy), width and yield are reported. The appearance...

article

Experimental study of the (K+,K0) interactions on 7Li close to threshold

M. Agnello, G. Beer, L. Benussi, M. Bertani, more

Physics Letters B > 2007 > 649 > 1 > 25-30

The inelastic charge exchange reaction (K+, K0) on ⁷ Li has been experimentally investigated close to threshold with the FINUDA spectrometer at the e+e− collider DAΦNE by searching for KS0 decays. It is the first time that this process has been studied at such low momentum. An upper limit of 2.0 mb (at 95% confidence level) has been measured for the total cross section.

article

DAΦNE monitored by FINUDA

M. Agnello, L. Benussi, M. Bertani, H.C. Bhang, more

Nuclear Inst. and Methods in Physics Research, A > 2007 > 570 > 1 > 205-215

The FINUDA spectrometer, devoted to hypernuclear physics and installed on the DAΦNE two rings collider at the Laboratori Nationali di Frascati, is able to monitor the relevant machine parameters, as luminosity, collision vertexes, c.m. energy and transversal momentum boost, during the process of data taking to study hypernuclear physics without affecting it. The collider parameters relevant to optimize...

article

Study of the proton weak decay of ¹² _ΛC_g.s. with FINUDA

The FINUDA Collaboration, M. Agnello, G. Beer, L. Benussi, more

The European Physical Journal A > 2007 > 33 > 3 > 251-254

. The FINUDA experiment studies the Λ -hypernuclei formation and decay using the reaction ( K ^- _stop,π^- induced by the low-momentum K^- from the deacy of the φ -meson produced at the (e ⁺, e ^- collider DAφ NE at the Laboratory Nazionali di Frascati of INFN. In this paper we present new data on the proton spectra following the weak decay of ¹² _ΛC .

article

The A(K^- _stop,Λd )A' reaction, a tool to observe [¯NNN] clusters

The FINUDA Collaboration, M. Agnello, G. Beer, L. Benussi, more

The European Physical Journal A > 2007 > 33 > 3 > 283-286

. This work presents experimental results obtained from a study of the K ^- _stop A → ΛdA' reaction, where A = ⁶ Li . The study concerns the distributions of the Λd invariant mass, which allows us to determine the structure of bound [K ^- ppn] systems in nuclei. A candidate of such clusters is identified in the present measurement, and its mass (binding energy), decay width and yield are reported. The...

article

Search for HΛ6 and HΛ7 with the (Kstop−,π+) reaction

M. Agnello, G. Beer, L. Benussi, M. Bertani, more

Physics Letters B > 2006 > 640 > 4 > 145-149

The production of neutron rich Λ-hypernuclei via the (Kstop−,π+) reaction has been studied using data collected with the FINUDA spectrometer at the DAΦNE ϕ-factory (LNF). The analysis of the inclusive π+ momentum spectra is presented and an upper limit for the production of HΛ6 and HΛ7 from ⁶ Li and ⁷ Li, is assessed for the first time.

article

A study of the proton spectra following the capture of K− in 6Li and 12C with FINUDA

M. Agnello, G. Beer, L. Benussi, M. Bertani, more

Nuclear Physics, Section A > 2006 > 775 > 1-2 > 35-50

Momenta spectra of protons emitted following the capture of K− in ⁶ Li and ¹² C have been measured with 1% resolution. The ¹² C spectrum is smooth whereas for ⁶ Li a well defined peak appears at about 500 MeV/c. The first observation of a structure in this region was identified as a strange tribaryon or, possibly, a K¯-nuclear state. The peak is correlated with a π−...

article

First results on 12ΛC production at DAΦNE

M. Agnello, G. Beer, L. Benussi, M. Bertani, more

Physics Letters B > 2005 > 622 > 1-2 > 35-44

Λ-hypernuclei are produced and studied, with the FINUDA spectrometer, for the first time at an e+e− collider: DAΦNE, the Frascati ϕ-factory. The slow negative kaons from ϕ(1020) decay are stopped in thin (0.2 g/cm ² ) nuclear targets, and Λ-hypernuclei formation is detected by measuring the momentum of the outgoing π−. A preliminary analysis on ¹² _Λ C shows an energy resolution...

article

First results from the FINUDA experiment

M. Agnello, G. Beer, L. Benussi, M. Bertani, more

Nuclear Physics, Section A > 2005 > 752 > Complete > 139-144

This paper provides a summary of the first results obtained by the FINUDA Collaboration in the field of hypernuclear physics. They range from the spectroscopic study of several A-hypernuclei to the observation of some non-mesonic decay modes. Hints on rare hypernuclear two-body decays, on neutron-rich hypernuclei and on deeply-bound kaonic nuclei are also reported.

article

Repeated but not acute clomipramine decreases the effect of N-methyl-d-aspartate receptor activation on serotonergic transmission between the raphe nuclei and frontal cortex

M. Pallotta, J. Segieth, F. Sadideen, P.S. Whitton

Neuropharmacology > 2001 > 41 > 3 > 294-300

The effect of acute or repeated treatment with the antidepressant clomipramine (CIM) on N-methyl-d-aspartate (NMDA) evoked changes in extracellular 5-hydroxytryptamine (5-HT) in the raphe nuclei and frontal cortex of the same rat has been studied using microdialysis. Acute injection of CIM (10 or 20mg/kg) caused an increase in raphe extracellular 5-HT but did not significantly alter extracellular...

article

Expression of PDGF-R, DCC, MDM2 and P16 in human gliomas

M. Varela, M. Pallotta, L. Puricelli, A. Morandi, more

European Journal of Cancer > 2001 > 37 > Supplement 6 > S343

article

5-39-09 Clinical outcome and survival in malignant gliomas after multidisciplinary treatment protocol

M. Varela, J. Lastiri, F. Kneizevich, C. Ciraolo, more

Journal of the Neurological Sciences > 1997 > 150 > Supplement 1 > S332-S333

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INFONA - science communication portal

Search results for: M. Pallotta

Baricitinib versus tocilizumab in critically ill COVID‐19 patients: A retrospective cohort study

Simplifying ARV Therapy in the Setting of Resistance

Implementation of a Stewardship Initiative on Respiratory Viral PCR‐based Antibiotic Deescalation

Chlorpyrifos exposure affects fgf8, sox9, and bmp4 expression required for cranial neural crest morphogenesis and chondrogenesis in Xenopus laevis embryos

Short interspersed DNA elements and miRNAs: a novel hidden gene regulation layer in zebrafish?

Construction of a barley bacterial artificial chromosome library suitable for cloning genes for boron tolerance, sodium exclusion and high grain zinc content

Physical analysis of the complex rye (Secale cereale L.) Alt4 aluminium (aluminum) tolerance locus using a whole-genome BAC library of rye cv. Blanco

The gas monitoring system for the Resistive Plate Chamber detector of the CMS experiment at LHC

Correlated Λd pairs from the Kstop−A→ΛdA′ reaction

Experimental study of the (K+,K0) interactions on 7Li close to threshold

DAΦNE monitored by FINUDA

Study of the proton weak decay of ¹² _ΛC_g.s. with FINUDA

The A(K^- _stop,Λd )A' reaction, a tool to observe [¯NNN] clusters

Search for HΛ6 and HΛ7 with the (Kstop−,π+) reaction

A study of the proton spectra following the capture of K− in 6Li and 12C with FINUDA

First results on 12ΛC production at DAΦNE

First results from the FINUDA experiment

Repeated but not acute clomipramine decreases the effect of N-methyl-d-aspartate receptor activation on serotonergic transmission between the raphe nuclei and frontal cortex

Expression of PDGF-R, DCC, MDM2 and P16 in human gliomas

5-39-09 Clinical outcome and survival in malignant gliomas after multidisciplinary treatment protocol

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