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Drug metabolism is a clinically important process occurring throughout the body, but principally in the liver, which determines the efficacy and toxicity of many of the most widely used drugs. Knowledge of drug metabolism is important in optimizing the use of drugs, maximizing benefits and minimizing harms.
Adverse drug reactions (ADRs) are a major clinical problem. Genetic factors can determine individual susceptibility to both dose-dependent and dose-independent ADRs. Determinants of susceptibility include kinetic factors, such as gene polymorphisms in cytochrome P450 enzymes, and dynamic factors, such as polymorphisms in drug targets. The relative importance of these factors will depend on the nature...
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