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Metabolic gene polymorphisms have previously been suggested as risk factors for renal cell carcinoma (RCC). These polymorphisms are involved in activation or detoxification of carcinogens in cigarette smoke which is another RCC risk factor. We evaluated gene–environment interactions between CYP1A1, GSTμ1 and smoking in a large population-based RCC case group. The Netherlands Cohort Study on diet and...
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