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Rationale Cocaine users have increased regional brain mu-opioid receptor (mOR) binding which correlates with cocaine craving. The relationship of mOR binding to relapse is unknown. Objective To evaluate regional brain mOR binding as a predictor of relapse to cocaine use is the objective of the study. Materials and methods Fifteen nontreatment-seeking, adult cocaine users were housed on a closed...
Rationale A single 90-mg dose of the cannabinoid CB1 receptor antagonist rimonabant attenuates effects of smoked cannabis in humans. Objectives The objective of this study is to evaluate whether repeated daily 40-mg doses of rimonabant can attenuate effects of smoked cannabis to the same extent as a single higher (90 mg) dose. Materials and methods Forty-two male volunteers received one of three...
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