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Background Fatigue is a common symptom of chronic hepatitis C virus (HCV) infection and a frequent side-effect of peginterferon/ribavirin (PR) therapy for HCV. This study evaluated the impact of adding the oral HCV NS3/4A protease inhibitor simeprevir to PR on patient-reported fatigue and health status among patients with chronic HCV genotype 1 infection enrolled in the Phase IIb PILLAR and ASPIRE...
Alkyl pyridyl sulfoxides 2 were prepared in high enantiomeric excess by resolution through inclusion complexation with a chiral host compound, (2R,3R) or (2S,3S)-(-)-trans-4,5-bis(hydroxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane 1. The X-ray crystallographic structure analysis of complex (R,R)-(-)-1 and (R)-(-)-2b is reported.
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