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Therapeutics utilizing siRNA are currently limited by the availability of safe and effective delivery systems. Cutaneous diseases, specifically ones with significant genetic components are ideal candidates for topical siRNA based therapy but the anatomical structure of skin presents a considerable hurdle. Here, we optimized a novel liposome and protein hybrid nanoparticle delivery system for the topical...
The genetic understanding of primary immunodeficiency diseases (PIDs) has rapidly advanced over the past 10 years; the number of known genetic causes now approaches 200. Most are very rare disorders that have increased our understanding of the crucial cellular pathways required for protection against infection by a wide variety of microbes. Although genetic disorders causing auto-inflammatory disease...
The field of primary immunodeficiency diseases (PID) has grown dramatically over the past 10 years, the number of defined genetic causes almost doubling to a current total of about 130 different defects. These often are very rare disorders which have taught us much about the crucial cellular pathways required for protection against infection from a wide variety of microbes. Although most clinicians...
Glioblastoma (GB) is the most common subtype of primary brain tumor in adults. These tumors are highly invasive, very aggressive, and often infiltrate critical neurological areas within the brain. The mean survival time after diagnosis of GB has remained unchanged during the last few decades, in spite of advances in surgical techniques, radiotherapy, and also chemotherapy; patients' survival ranges...
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