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The steady-state rate of glucose oxidation through the mitochondrial TCA cycle (V TCA ) was measured in acid extracts of 10- and 30-day-old cerebral cortex of rats receiving [1- 13 C]glucose intravenously and in neocortical slices superfused in vitro with the same isotope. TCA cycle flux was determined for each age group based on metabolic modeling analysis of the isotopic...
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