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The pseudomonad protein, carboxypeptidase G2 (CPG2), is a prodrug‐activating enzyme utilized in the targeted chemotherapy strategies of antibody‐ and gene‐directed enzyme prodrug therapy (ADEPT and GDEPT). We have developed a noninvasive imaging approach to monitor CPG2 activity in vivo that will facilitate the preclinical and clinical development of CPG2‐based ADEPT and GDEPT strategies. Cleavage...
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