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Presensitization against a broad array of human leukocyte antigens (HLA) is associated with prolonged waiting times and inferior graft survival in kidney transplantation. Since the late 1960s, a positive lymphocytotoxic crossmatch has been considered a contraindication for kidney transplantation and solutions, such as enrollment of eligible patients in the Acceptable Mismatch Program of Eurotransplant...
The relationship of positive lymphocytotoxic T-cell and B-cell crossmatches as well as that of flow-cytometric crossmatches with transplant survival was analyzed in kidney, heart, and liver transplants from deceased donors reported to the international Collaborative Transplant Study. High rates of hyperacute rejection were not observed with any type of crossmatch test or type of organ transplant,...
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