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We have previously reported that kidney transplant recipients with enzyme-linked immunoabsorbent assay–reactive human leukocyte antigen (HLA) class I and II antibodies are at an increased risk for graft failure. To determine whether positivity for both classes of HLA antibodies before transplantation can serve as an indicator for identification of high-risk patients, the impact of preformed HLA antibodies...
It is a matter of debate whether pretransplant anti-human leukocyte antigen (HLA) class II antibodies contribute to the increased graft rejection rate found in presensitized recipients. We investigated the influence of preformed anti-HLA class II antibodies on graft survival in 5949 cadaver kidney transplants. Pretransplant recipient sera were tested in enzyme-linked immunosorbent assay (ELISA) for...
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