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The many pharmacologically diverse molecules that are able to reduce neuropathic pain might do so through a common action on neuronal Na + channels. Here we compare the potency for relieving allodynia from rat nerve root (L5-L6) ligation by mexiletine enantiomers known to stereoselectively inhibit Na + channels. After programmed intravenous infusions of R(-)- and S(+)-mexiletine to...
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