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G protein‐coupled receptor 119 (GPR119) is a member of the GPCR family promising to be the target for type 2 diabetes mellitus (T2DM) treatment. In this work, 30 novel compounds were designed, synthesized, and evaluated by in vitro cAMP activation assay, where compounds II–14 and II–18 showed the best potency with EC50 values of 69 and 99 nM, respectively. In the oral glucose tolerance test, compound...
In an attempt to develop potent anti‐HIV drugs, 20 andrographolide derivatives were designed, synthesized, and evaluated for their in vitro anti‐HIV activity. The screening results revealed that five compounds showed potent anti‐HIV activities with therapeutic indices (TI) above 10. The most promising compound 6f shows a significant TI close to 34.07, with the potency to be a new lead.
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