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The insulin‐like growth factor II receptor (IGF‐IIR) induces myocardial hypertrophy under various pathological conditions like diabetes and hypertension via G protein receptors like Gαq or Gαs. Increased expression of the ligand IGF II and IGF‐IIR induces pathological hypertrophy through downstream signaling mediators such as calcineurin, nuclear factor of activated T cells 3 and calcium‐calmodulin...
Cardiac hypertrophy is a common phenomenon observed in progressive heart disease associated with heart failure. Insulin‐like growth factor receptor II (IGF‐IIR) has been much implicated in myocardial hypertrophy. Our previous studies have found that increased activities of signaling mediators, such as calcium/calmodulin‐dependent protein kinase II (CaMKII) and calcineurin induces pathological hypertrophy...
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