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This paper indicates that in ventricular myocytes when the SR (sarcoplasmic reticulum) is pharmacologically inhibited, the intracellular Ca2+concentration rapidly increases during Ca2+ entrance (0-70 ms), whereas the decay of Ca2+ is slow; in the absence of fluorescent dye, large Ca2+ concentration gradients might develop near the cell membrane; intracellular Ca2+ distribution is tightly regulated...
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