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The immune response against platelets is a complex process involving many aspects of the innate and adaptive immune system. Immune destruction of platelets and megakaryocytes and the thrombocytopenia that ensues can cause different clinically significant haematological disorders such as foetal and neonatal alloimmune thrombocytopenia (FNAIT), transfusion‐induced platelet refractoriness or immune thrombocytopenia...
Background and ObjectivesThe primary hemostatic nature of platelets closely links these cellular fragments with the immune system. Platelet aggregation and activation on damaged endothelium initiates secretion of their granule contents and expression of both pro‐ and anti‐inflammatory molecules. This review will highlight some of the major non‐hematologic functions of platelets.
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