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Alcohol exposure has detrimental effects on both the developing and mature brain. Endoplasmic reticulum (ER) stress is one of the mechanisms that contributes to alcohol‐induced neuronal damages. Mesencephalic astrocyte‐derived neurotrophic factor (MANF) is an ER stress‐responsive protein and is neuroprotective in multiple neuronal injury and neurodegenerative disease models. MANF deficiency has been...
Disruption of iron homeostasis in the brain of Parkinson's disease (PD) patients has been reported for many years, but the underlying mechanisms remain unclear. To investigate iron metabolism genes related to PTEN‐induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD‐associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted...