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Delivery System for microRNA
In article number 2104359, Xiaoxiao Cai and co‐workers present a tetrahedral framework nucleic acids‐based delivery system for miRNA. miRNA is protected extracellularly, and efficiently released in response to intracellular RNase after cellular entrance. Similarly, Chinese philosophy “Chuang Tzu” portrayed the transformation of the legendary fish “Kun” (protected microRNA)...
MicroRNAs (miRs) play an important role in regulating gene expression. Limited by their instabilities, miR therapeutics require delivery vehicles. Tetrahedral framework nucleic acids (tFNAs) are potentially applicable to drug delivery because they prominently penetrate tissue and are taken up by cells. However, tFNA‐based miR delivery strategies have failed to separate the miRs after they enter cells,...
During the past decade, a series of thermo-responsive hydrogels based on poly(N-isopropylacrylamide) (PNIPAM) were prepared for drug delivery. However, the release performance of those hydrogels was limited because the LCST (lower critical solution temperature) of PNIPAM (about 32 °C) is slightly lower than human body temperature, and the drug loading is complicated. To develop a new drug delivery...
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