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Mesalamine (5-aminosalicylic acid) is the drug of choice for the treatment of Crohn’s disease. A scheme for the synthesis of 5-aminosalicylic acid (5-ASA) conjugates of dextrans was developed with a focus on Crohn’s disease applications. Dextrans were oxidised using sodium periodate (NaIO 4 ), where the aldehyde groups formed were coupled with the α-amino (–NH 2 ) group of 5-ASA. The...
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