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Recent advances in optical molecular imaging technology have led to great improvements in image resolution, and are increasingly being applied to non-invasively delineate in vivo physiological and pathological processes at cellular and molecular levels. It provides the potential for the understanding of integrative biology, earlier detection and characterization of disease and the evaluation of treatment...
Bioluminescence imaging (BLI) offers an alternative opportunity for non-invasively visualizing biological processes at the physiological and molecular levels in whole animals. Tomographic bioluminescence imaging (TBI) can further translate planar imaging into three-dimensional quantitative bioluminescent source distribution. Although many reconstruction methods have been developed, efforts are still...
Tomographic bioluminescence imaging suffers from poor imaging robustness, since it is severely affected by selection of regularization parameter (RP) and initialization for source distribution. In this paper, a global-inexact-Newton based reconstruction methodology, which is regularized by a dynamic sparse term, is demonstrated for in vivo tomographic imaging. The novel method can enhance higher imaging...
Fluorescence molecular tomography has become a promising technique for in vivo small animal imaging, and has many potential applications. Due to the ill-posed and the ill-conditioned nature of the problem, Tikhonov regularization is generally adopted to stabilize the solution. However, the result is usually over-smoothed. In this study, the sparsity of the fluorescent source is used as a priori information...
Fluorescence molecular tomography has become a promising technique for in vivo small animal imaging and has many potential applications. Due to the ill-posed and the ill-conditioned nature of the problem, Tikhonov regularization is generally adopted to stabilize the solution. However, the result is usually over-smoothed. In this letter, the third-order simplified spherical harmonics approximation...
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