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Small animal imaging provides a powerful tool to study cancer in animal models. To monitor therapeutic response, serial in vivo images are acquired at different time points. Accurate image registration is needed to improve the quantification of changes over time. However, mouse body is extremely flexible and deformable, mouse image registration is challenging. In this paper, we present a deformable...
We are investigating image processing and analysis techniques to improve the ability of dual-energy digital radiography (DR) for the detection of cardiac calcification. Computed tomography (CT) is an established tool for the diagnosis of coronary artery diseases. Dual-energy digital radiography could be a cost-effective alternative. In this study, we use three-dimensional (3D) CT images as the "gold...
In vivo small animal imaging provides a powerful tool for the study of a variety of diseases. Magnetic resonance imaging (MRI) has become an established technology for the assessment of therapies. In this study, we used high-resolution MRI to evaluate polycystic kidney disease (PKD) in transgenic mice. We used a customized mouse coil to acquire serial MR images from both wide-type and transgenic PKD...
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