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Most proteins form macromolecular complexes to perform their biological functions. With the increasing availability of large amounts of high-throughput protein-protein interaction (PPI) data, a vast number of computational approaches for detecting protein complexes have been proposed to discover protein complexes from PPI networks. However, such approaches are not good enough since the high rate of...
Most existing methods used for computing semantic similarity don't take full consideration of related factors, therefore they not only fail to handle identical annotations but also show a strong bias toward well-annotated gene or gene products. Concerning these problems, we proposed a new hybrid method based on multiple factors that affect the semantic similarity of Gene Ontology (GO) terms. The new...
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