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A bio‐responsive microneedle‐based patch, integrated with a rhodamine‐stained glucose‐signal amplifier and calcein‐AM‐stained pancreatic β‐cell capsules, is developed by Z. Gu and co‐workers. This “smart cell patch”, described on page 3115, effectively regulates the blood glucose level of type‐1 diabetic mice, achieving a reduction for over 10 h. Image credit: Yanqi Ye.
An innovative microneedle (MN)‐based cell therapy is developed for glucose‐responsive regulation of the insulin secretion from exogenous pancreatic β‐cells without implantation. One MN patch can quickly reduce the blood‐sugar levels (BGLs) of chemically induced type‐1 diabetic mice and stabilize BGLs at a reduced level for over 10 h.
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