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Background
The immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is crucial for preventing infections and relapse and enhancing graft‐versus‐tumor effects. B cells play an important role in humoral immunity and immune regulation, but their reconstitution after allo‐HSCT has not been well studied.
Methods
In this study, we analyzed the dynamics of B cells...
In lithium‐ion batteries (LIBs), the stabilized capacities of transition metal compound anodes usually exhibit higher values than their theoretical values due to the interfacial charge storage, the formation of reversible electrolyte‐derived surface layer, or interfacial magnetization. But the effectively utilizing the mechanisms to achieve novel anodes is rarely explored. Herein, a novel nanosized...
Tumor‐Targeting Nanozymes
In article number 2102624, Qi Zhao and co‐workers demonstrate that a nanozyme‐mediated photothermal‐nanocatalytic effect disrupts the tumor extracellular matrix and induces cancer cell death. The alterations in the tumor microenvironment ultimately promote tumor infiltration and immune response of CAR T cells against solid tumors.
Targeting B7‐H3 chimeric antigen receptor (CAR) T cells has antitumor potential for therapy of non‐small cell lung cancer (NSCLC) in preclinical studies. However, CAR T cell therapy remains a formidable challenge for the treatment of solid tumors due to the heterogeneous and immunosuppressive tumor microenvironment (TME). Nanozymes exhibit merits modulating the immunosuppression of the tumor milieu...