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Gold-nanoparticles can be used as a robust tool for bio-sensing based on localized surface plasmon resonance (LSPR). Both local refractive index change and self-assembly of the nanoparticles can lead to some spectral shifts of the LSPR extinction peak. Using different mechanisms of LSPR peak shifts, two types of transducers are set up to detect the streptavidin concentration through the specific recognition...
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