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The present study demonstrates that derivatized dextrans, such as carboxylmethyl dextran benzylamide and carboxymethyl dextran benzylamide sulfonate, specifically interact with HIV-1 envelope glycoproteins (rgp160 and rgp41) with significantly higher affinities than those observed for dextran sulfate (MW 8 kDa). These results suggest the possible involvement in HIV infectivity of surface membrane...
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