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Objectives
Glial cell activation contributes to the inflammatory response and occurrence of epilepsy. Our preliminary study demonstrated that the long non‐coding RNA, H19, promotes hippocampal glial cell activation during epileptogenesis. However, the precise mechanisms underlying this effect remain unclear.
Materials and methods
H19 and let‐7b were overexpressed or silenced using an adeno‐associated...
Objective
We aimed to study the networks’ mechanism of metabolic covariance networks in mesial temporal lobe epilepsy (mTLE), through examining the brain value of fluorine‐18‐fluorodeoxyglucose positron emission tomography (18F‐FDG‐PET).
Methods
18F‐FDG‐PET images from 16 patients with mTLE were analyzed using local and global metabolic covariance network (MCN) approaches, including whole metabolic...
Gephyrin, which is a postsynaptic scaffolding protein participated in clustering GABAA receptors at inhibitory synapses, has been reported to be involved in temporal lobe epilepsy (TLE) recently. Here, we investigate gephyrin protein expression in the temporal lobe epileptic foci in epileptic patients and experimental animals in order to explore the probable relationship between gephyrin expression...
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