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The modulatory effects of spermine, histamine, and ifenprodil on recombinant N-methyl-d-aspartate (NMDA) receptors expressed from the NR1a and 4 (NR2D) subunits were studied by voltage-clamp recording in Xenopus oocytes. Spermine had no effect on responses to glutamate and glycine at NR1a/ 4 receptors. None of the four previously described effects of spermine, all of which are seen at NR1a receptors...
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