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Osteocytes sense the mechanical loading and weightlessness, and orchestrate bone remodeling by directing both osteoblast and osteoclast functions. Previous studies mostly focused on the impact of mechanical loading or microgravity on the osteocyte changes in themselves. However as the mechanosensors, it is more meaningful to make clear whether and how the mechanosensitivity of osteocytes affected...
Osteocytes, as most abundant cells and major mechanical sensor in bone, play an important role in the mechanism of microgravity-induced bone loss. The response of osteocytes to fluid flow stress under simulated microgravity was investigated in this study. MLO-Y4, an osteocyte-like cell line, was cultured under simulated microgravity condition for 5 days. Then cells were sheared at 15dyn/cm 2 ...
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