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Background: The PRAISE study demonstrated that amlodipine, a new dihydropiridine Ca 2+ channel antagonist, improves the prognosis of heart failure caused by nonischemic cardiomyopathy. However, the precise mechanisms by which amlodipine improves the prognosis have not been elucidated. We had previously reported that the contractility of aortic smooth muscle in cardiomyopathic hamsters...
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