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The use of amphiphilic block copolymers (ABC)s in experimental medicine and pharmaceutical sciences has a long history and is expecting rapid development. Poly(ethylene oxide)–block–poly(amino acid) and poly(ethylene oxide)–block–polyesters represented the most important two types of ABCs for development of nanocarriers for drug/gene delivery. In this chapter, we provided an update on several chemical...
Self-assembly of amphiphilic block co-polymers composed of poly(ethylene oxide) (PEO) as the hydrophilic block and poly(ether)s, poly(amino acid)s, poly(ester)s and polypropyleneoxide (PPO) as the hydrophobic block can lead to the formation of nanoscopic structures of different morphologies. These structures have been the subject of extensive research in the past decade as artificial mimics of lipoproteins...
Purposes To develop multifunctional RGD-decorated poly(ethylene oxide)-b-poly(ester) based micelles and assess their pH-triggered core degradation and targeted drug release in tumor cells that overexpress RGD receptors. Methods Novel poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) based copolymers modified with RGD ligands on PEO and pendent functional groups on PCL, i.e., GRGDS-PEO-b-poly(α-benzylcarboxylate-ε-caprolactone)...
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