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Abstract We show herein that human DNA topoisomerase II is functional in yeast. It can complement a yeast temperature-sensitive mutation in topoisomerase II. The effect on human topoisomerase II of a number of topoisomerase II inhibitors was analysed in a yeast in vivo system and compared with that of human topoisomerase II and wild-type yeast topoisomerase II. A drug permeable yeast strain (JN394...
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