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Rationale. The discriminative stimulus effects of zolpidem in squirrel monkeys trained at doses greater than or equal to 3.0mg/kg differ from those of conventional benzodiazepines (BZs), but the extent to which these effects reflect the selectivity of zolpidem for GABAA/1 receptors is not known. Objectives. The present study investigated the ability of GABAA/1-preferring agonists to substitute for...
Abstract. Rationale: Conventional benzodiazepines (BZs), clinically used for treatment of anxiety and insomnia, bind to GABAA receptors containing 1, 2, 3, or 5subunits. The role of these different GABAA receptor subtypes in mediating the subjective effects of BZs remains largely unknown. Objective: The purpose of the present study was to evaluate the role of GABAA receptors containing the 1 or 5subunits...
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