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Background We aim to address one question: do cancer vs. normal tissue cells execute their transcription regulation essentially the same or differently, and why? Methods We utilized an integrated computational study of cancer epigenomes and transcriptomes of 10 cancer types, by using penalized linear regression models to evaluate the regulatory effects of DNA methylations on gene expressions. ...
Cold stress is a significant factor influencing global rice production and quality. In the present study, two strong rice cold tolerance introgression lines (ILs) (IL5335 and IL5243) derived from Oryza sativa L. mating with O. rufipogon Griff. were used to evaluate the relationship between the alteration of DNA methylation and phenotypic stability using methylation sensitive...
Background Atherosclerosis is a heterogeneously distributed disease of arteries in which the endothelium plays an important central role. Spatial transcriptome profiling of endothelium in pre-lesional arteries has demonstrated differential phenotypes primed for athero-susceptibility at hemodynamic sites associated with disturbed blood flow. DNA methylation is a powerful epigenetic regulator of endothelial...
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