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Actions of the N ε -(carboxymethyl)lysine (CML) were investigated on the neovascularization of cultured retinal explants in streptozotocin (STZ)-diabetic rats at the early and the advanced stages. The onset and growth of sprouting and buds in the retinal explant (retinal neovascularization) in the early diabetes were similar to those in the age-matched young control. However, the retinal neovascularization...
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