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Intrinsic dissolution, powder dissolution, and the pharmacokinetics (PK) of 12 carboxylic acid co‐crystals of AMG 517 were determined and compared. Dissolution studies were performed in fasted simulated intestinal fluid (FaSIF). A control dissolution experiment was conducted with the free base in FaSIF plus sorbic acid to compare with the AMG 517 sorbic acid co‐crystal (SRA). Suspension formulations...
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