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This population-based study assesses whether a proposed five-tiered Gleason grade grouping (GGG) system predicts prostate cancer–specific mortality (PCSM). Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 331320 prostate cancer patients who had primary and secondary Gleason patterns diagnosed between January 2006 and December 2012. We used the Fine and Gray proportional...
Objectives To define high risk prostate cancer using prostate cancer specific mortality as the key outcome metric. Methods Data from two population based cohorts of men from Connecticut who were diagnosed with localized prostate cancer were analyzed to determine the natural history of prostate cancer and the impact of treatment on long term survival. Results Men with Gleason 7–10 prostate cancer...
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