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BackgroundInherited conditions affecting genetic aberration, viral oncogenesis, reduced immune surveillance, and long‐lasting antigen stimulation may build the way to lymphomagenesis in humans.
MethodsWe extracted from the database of 4 consecutive trials for pediatric non‐Hodgkin lymphoma (NHL) all cases with an associated genetic disease.
ResultsAmong 1,430 patients, 34 (2.4%) had an associated...
Background
Treatment intensification was considered a suitable strategy to increase the cure rate of lymphoblastic lymphoma (LBL) in children.
Procedure
The AIEOP LNH‐97 trial was run between 1997 and 2007 for newly diagnosed LBL in patients aged less than 18 years. Treatment schedule was based on the previous, LSA2‐L2 derived, AIEOP LNH‐92 protocol. Modifications included: increased dose of upfront...
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