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Background
High‐dose chemotherapy with autologous stem cell rescue (HDC‐ASCR) has improved event‐free survival for children with high‐risk neuroblastoma. Common regimens include carboplatin/etoposide/melphalan (CEM), busulfan/melphalan (BuMel), and tandem HDC‐ASCR [thiotepa/cyclophosphamide (TC) followed by CEM]. To complement clinical trial data and to evaluate the clinical burden associated with...
Background
High‐dose chemotherapy with autologous stem cell rescue (ASCR) is a key component of high‐risk neuroblastoma therapy. Resources required to support patients treated with ASCR conditioning regimens [carboplatin/etoposide/melphalan (CEM) and busulfan/melphalan (BuMel)] have not been directly compared.
Procedure
An administrative database was used to analyze resource utilization and outcomes...
BACKGROUND:Clinical trials in pediatric acute myeloid leukemia (AML) determine induction regimen standards. However, these studies lack the data necessary to evaluate mortality trends over time and differences in resource utilization between induction regimens. Moreover, these trials likely underreport the clinical toxicities experienced by patients.
METHODS:The Pediatric Health Information System...
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