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Background: The purpose of this study was to determine the prevalence of substance use disorders (substance abuse or substance dependence: SA/SD) in a large sample of Bipolar Type I (BPI) patients drawn from the Costa Rican population and to describe the effects of SA/SD on the course of their bipolar disorder. Method: 110 subjects from two high-risk (for BPI) Costa Rican pedigrees and 205 unrelated...
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