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Gamma-knife radiosurgery is one of the only means of treating otherwise inoperable intracranial neoplasia. At present the mechanism by which single-dose γ-radiation reduces tumor bulk is unknown. Using the human mammary cell line MCF-7 to represent a metastatic tumor often treated by γ-knife radiosurgery, we show here that γ-radiation provided by the γ knife dose dependency reduced growth and a component...
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