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Metal–Organic Frameworks Armored Antibiotics
In article number 2204906, Jie Zhao, Tingting Tang, Shengbing Yang, and co‐workers present metal–organic frameworks (MOFs)‐armored antibiotics as super penetrating bombs that effectively eradicate two types of persistent bacteria, intracellular and biofilm bacteria. The nanoscale MOFs augment antibiotic permeability, acting as a powerful weapon to combat...
Persistent bacteria, such as intracellular and biofilm bacteria, are critical challenges in clinic treatment because they are refractory to antibiotics management under the shelter of cytomembrane and biofilm. Conventional strategies to combat intracellular bacteria are using high doses of antibiotics, which may bring the risk of drug resistance, and debridement of the biofilm increases patients’...
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