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Compound FLZ is a synthetic novel derivate of natural squamosamide, which has potent neuroprotective effects based on our previous study. We are now aiming to investigate the effects of FLZ on cerebral blood flow (CBF), infarct volume, neurological function, heat shock protein 70 (Hsp70), and Hsp27 expression in transient focal ischemia. For this goal, an animal model of middle cerebral artery occlusion...
One of the main limitations of intracerebral hemorrhage (ICH) research is lack of reproducible animal models. ICH appears to be associated with a volume of edema and ischemic injury surrounding the hematoma that may be reduced by nimodipine due to its vasodilating and cytoprotective effects. The present study was designed to produce a modified ICH model in mice based on the double-injection method...
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