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Drosophila ovary is recognized as one of the best model systems to study stem cell biology in vivo. We had previously identified an autonomous role of the histone H1 in germline stem cell (GSC) maintenance. Here, we found that histone H1 depletion in escort cells (ECs) resulted in an increase of spectrosome-containing cells (SCCs), an ovary tumor-like phenotype. Further analysis showed that the Dpp...
Our laboratory and others have shown that overexpression of Dlx5 stimulates osteoblast differentiation. Dlx5 −/− /Dlx6 −/− mice have more severe craniofacial and limb defects than Dlx5 −/− , some of which are potentially due to defects in osteoblast maturation. We wished to investigate the degree to which other Dlx genes compensate for the lack of Dlx5, thus allowing normal...
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