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This report characterizes the influence of a pharmacological concentration of estradiol on growth arrest and cell death in MCF-7 breast tumor cells, with a focus on elements of the Rb-E2F cell-cycle regulatory pathway. Continuous exposure of MCF-7 breast tumor cells to 100 μM estradiol produces a marked reduction in the G1 and S phase populations and a corresponding increase in the G2/M population...
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