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Aims
Comparative efficacy between fibroblast growth factor 21 (FGF21) and vildagliptin on metabolic regulation, cardiac mitochondrial function, heart rate variability (HRV), and left ventricular (LV) function is not known. We hypothesized that FGF21 and vildagliptin share a similar efficacy in improving these parameters in high fat diet (HFD)‐induced obese‐insulin resistant rats.
Methods
Twenty‐four...
ObjectivesReducing the expression of endothelial cell adhesion molecules is conducive to the decrease of inflammation‐induced vascular complications. In this study, we observed pitavastatin on expression of vascular cell adhesion molecule‐1 (VCAM‐1) and its influence on VCAM‐1's target gene miR‐126 in endothelial cells. The purpose of this study is to explore the mechanism of pitavastatin in prevention...
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