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There is no evidence on the precise role of synaptic Zn2+ signaling on the retention and recall of recognition memory. On the basis of the findings that intracellular Zn2+ signaling in the dentate gyrus is required for object recognition, short‐term memory, the present study deals with the effect of spatiotemporally blocking Zn2+ signaling in the dentate gyrus after LTP induction and learning. Three‐day‐maintained...
The role of perforant pathway‐dentate granule cell synapses in cognitive behavior was examined focusing on synaptic Zn2+ signaling in the dentate gyrus. Object recognition memory was transiently impaired when extracellular Zn2+ levels were decreased by injection of clioquinol and N,N,N′,N′‐tetrakis‐(2‐pyridylmethyl) ethylendediamine. To pursue the effect of the loss and/or blockade of Zn2+ signaling...
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