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Intrinsic transcription termination sites generally contain a tract of adenines in the DNA template that yields a tract of uracils at the 3′ end of the nascent RNA. To understand how this base sequence contributes to termination of transcription, we have investigated two nucleic acid structures. The first is the RNA–DNA hybrid that contains the uracil tract 5′-rUUUUUAU-3′ from the tR2 intrinsic terminator...
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