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For ion channels, the transmembrane potential plays a critical role by acting as a driving force for permeant ions. At the microscopic level, the transmembrane potential is thought to decay nonlinearly across the ion permeation pathway because of the irregular three-dimensional shape of the channel's pore. By taking advantage of the current structural and functional understanding of cyclic nucleotide-gated...
Martentoxin as a 37-residue peptide was capable of blocking large-conductance Ca2+-activated K+ (BK) channels in adrenal medulla chromaffin cells. This study investigated the pharmacological discrimination of martentoxin on BK channel subtypes. The results showed that the iberiotoxin-insensitive neuronal BK channels (α+β4) could be potently blocked by martentoxin (IC50=∼80nM). In contrast, the iberiotoxin-sensitive...
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