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Dysregulation of Wnt/β-catenin pathway plays a central role in early events in colorectal carcinogenesis. We examined the effect of quercetin, a famous anti-tumor agent, against β-catenin/Tcf signaling in SW480 cells. Quercetin inhibited the transcriptional activity of β-catenin/Tcf in SW480 and also in HEK293 cells transiently transfected with constitutively active mutant β-catenin gene, whose product...
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