Search results for: Chen Su

Items from 1 to 20 out of 351 results

article

Systematic synthesis and identification of monolignol pathway metabolites

Chung‐Ting Kao, Fan‐Wei Yang, Meng‐Chen Wu, Tzu‐Huan Hung, more

Monolignol serves as the building blocks to constitute lignin, the second abundant polymer on Earth. Despite two decades of diligent efforts, complete identification of all metabolites in the currently proposed monolignol biosynthesis pathway has proven elusive. This limitation also hampers their potential application. One of the primary obstacles is the challenge of assembling a collection of all...

article

Copper Iodide Hybrid with Unique Cu₃I₃ Trimeric Inorganic Functional Unit and Far‐red/Near‐infrared Emission

Haibo Li, Chen Su, Qianqian Wang, Jing Yang, more

European Journal of Inorganic Chemistry > 27 > 24 > n/a - n/a

In this paper, a neutral copper iodide hybrid with unique Cu₃I₃ trimeric inorganic functional unit is successfully fabricated using 5,6,7,8‐tetrahydroquinoxaline (L) with large steric‐hindrance group as the organic ligand. The hybrid owns a one‐dimensional (1D) extended polymeric structure in the form of Cu₃I₃(L)₂. As a CuI‐based hybrid, 1D‐Cu₃I₃(L)₂ has an infrequent far‐red/near‐infrared emission,...

article

Controllable Dopamine Conjugation Boosts Fluorescence, Biocompatibility, and PET Imaging‐Guided Toxicity Assessment of Polycations

Mingming Zhao, Xinhao Guo, Chen Su, Meng Li, more

Advanced Functional Materials > 34 > 34 > n/a - n/a

As well known in bioactives delivery and cancer/inflammation theranostics, polycations have recently extended their biomedical potentials in reducing visceral fat, embolizing body fluid, modulating blood coagulation, and ameliorating hyperammonemia. However, positive charges that dominate various action mechanisms, often raise risks in biosafety concerns. Also, the lack of intrinsic imaging properties...

article

Discovery of N,N'‐diarylurea molecules with activity against multidrug‐resistant Staphylococcus aureus

Hui‐Hui Yeo, Yu‐Hsuan Jao, Fan‐Wei Yang, Min‐Hsuan Kuo, more

Archiv der Pharmazie > 357 > 8 > n/a - n/a

The emergence and global spread of methicillin‐resistant Staphylococcus aureus (MRSA) pose a serious threat to public health, underscoring the urgent need for novel antibacterial interventions. Here, we screened 18 newly synthesized N,N’‐diarylurea derivatives to identify compounds with activity against MRSA. Our investigations led to the discovery of a small molecule, SCB‐24, which exhibited promising...

article

Comparative effectiveness and tolerability of calcitonin gene‐related peptide (CGRP) monoclonal antibodies and onabotulinumtoxinA in chronic migraine: A multicenter, real‐world study in Taiwan

Yen‐Feng Wang, Fu‐Chi Yang, Lu‐An Chen, Ting‐Yu Chang, more

European Journal of Neurology > 31 > 9 > n/a - n/a

Objective To compare the real‐world effectiveness and tolerability of calcitonin gene‐related peptide (CGRP) monoclonal antibodies (mAbs) and onabotulinumtoxinA in chronic migraine (CM) patients. Methods This multicenter study involved retrospective analysis of prospectively collected data of CM patients treated with CGRP mAbs or onabotulinumtoxinA, including difficult‐to‐treat (DTT) patients (i...

article

Solitary central nervous system relapse in acute promyelocytic leukemia

Truong Pham Hong Diem, Yu‐Chen Su, Mei‐Yu Su, Chieh‐Lin Jerry Teng

International Journal of Laboratory Hematology > 46 > 4 > 587 - 588

article

Multipathway regulation induced by 4‐(phenylsulfonyl)morpholine derivatives against triple‐negative breast cancer

Fan‐Wei Yang, Te‐Lun Mai, Ying‐Chung Jimmy Lin, Yu‐Chen Chen, more

Archiv der Pharmazie > 357 > 5 > n/a - n/a

Phenotypic drug discovery (PDD) is an effective drug discovery approach by observation of therapeutic effects on disease phenotypes, especially in complex disease systems. Triple‐negative breast cancer (TNBC) is composed of several complex disease features, including high tumor heterogeneity, high invasive and metastatic potential, and a lack of effective therapeutic targets. Therefore, identifying...

article

Activating Tumor‐Selective Liquid Metal Nanomedicine through Galvanic Replacement

Junjie Yan, Jinqiang Wang, Xinyu Wang, Donghui Pan, more

Advanced Materials > 36 > 5 > n/a - n/a

Advanced chemotherapeutic strategies including prodrug and nanocatalytic medicine have significantly advanced tumor‐selective theranostics, but delicate prodrug screening, tedious synthesis, low degradability/biocompatibility of inorganic components, and unsatisfied reaction activity complicate treatment efficacies. Here, the intrinsic anticancer bioactivity of liquid metal nanodroplets (LMNDs) is...

article

Activating Tumor‐Selective Liquid Metal Nanomedicine through Galvanic Replacement (Adv. Mater. 5/2024)

Junjie Yan, Jinqiang Wang, Xinyu Wang, Donghui Pan, more

Advanced Materials > 36 > 5 > n/a - n/a

Cancer Therapy In article number 2307817, Junjie Yan, Min Yang, Zhen Gu, and co‐workers discover that the intrinsic anticancer bioactivity of liquid metal nanodroplets (<30 nm) can be activated via the galvanic replacement reaction with endogenous Cu²⁺ ions. This chemotherapy strategy, which leverages endogenous nutrients and features tumor‐selective carrier‐to‐drug conversion, dual anticancer...

article

The Impact of Analyst, CEO, and Firm Reputations on Investors in the UK and Japanese Stock Markets

Simon Hussain, Chen Su

British Journal of Management > 35 > 1 > 259 - 280

We examine the importance of multiple agents’ reputations on the market's reaction to analysts’ stock recommendation revisions (analyst revisions), individually and interactively, in the UK and Japanese stock markets. We find some notable variations in reputation effects between the two markets. In the UK, analyst reputation amplifies the market's reaction to analyst revisions, while in Japan, analyst...

article

A Behavioural Appraisal of Regulatory Financial Reforms and Implications for Corporate Management

Samah El Hajjar, Bartosz Gebka, Darren Duxbury, Chen Su

British Journal of Management > 35 > 1 > 415 - 433

Financial markets play a vital role in shaping corporate behaviour, impacting corporate financial decisions ranging from investment and mergers/acquisitions to payout policies and management renumeration. Financial markets, however, are prone to irrational sentiments to trade, driving prices away from fundamental values, with the potential to distort corporate decisions and, hence, corporate efficiency...

article

Personalized lifetime prediction of survival and treatment benefit in patients with heart failure with reduced ejection fraction: The LIFE‐HF model

Pascal M. Burger, Gianluigi Savarese, Jasper Tromp, Carly Adamson, more

European Journal of Heart Failure > 25 > 11 > 1962 - 1975

Aims Although trials have proven the group‐level effectiveness of various therapies for heart failure with reduced ejection fraction (HFrEF), important differences in absolute effectiveness exist between individuals. We developed and validated the LIFEtime‐perspective for Heart Failure (LIFE‐HF) model for the prediction of individual (lifetime) risk and treatment benefit in patients with HFrEF. ...

article

B‐Box proteins BBX28 and BBX29 interplay with PSEUDO‐RESPONSE REGULATORS to fine‐tune circadian clock in Arabidopsis

Yingjun Yu, Chen Su, Yuqing He, Lei Wang

Plant, Cell & Environment > 46 > 9 > 2810 - 2826

As an endogenous time‐keeping mechanism, the circadian clock benefits plant fitness and adaptation to the rhythmically changed diel environments. The key components within the core oscillator of plant circadian clock have been extensively characterised, however, the fine‐tuning circadian regulators are still less identified. Here, we demonstrated that BBX28 and BBX29, the two B‐Box V subfamily members...

article

The velocity field characteristics of high‐viscosity fluids falling film flow down clamped channels

Yongjun Wang, Chen Su, Shichang Chen, Xianming Zhang, more

The Canadian Journal of Chemical Engineering > 101 > 7 > 4270 - 4286

The complexity of falling film flow has been studied in many industrial applications. In this work, the velocity field of high‐viscosity fluids falling film flow down clamped channels was investigated numerically and experimentally. The results show that the numerical simulation results are consistent with the experimental results, and the characteristics of the velocity field are related to the fluid...

article

The performance of UK stock recommendation revisions: Does brokerage house reputation matter?

Chen Su, Hanxiong Zhang, Nathan Lael Joseph

International Journal of Finance & Economics > 27 > 3 > 3051 - 3070

Our study examines the impact of brokerage house (BH) reputation on the performance of investment strategies following stock recommendation revisions in the UK stock market. We develop two alternative proxies for BH reputation based either on the past positions on the annual Institutional Investor (II) All‐Europe Research Team or on the past recommendation performance of BHs. We find that BH reputation...

article

Edible folic acid and medicinal folinic acid produce cardioprotective effects in late‐stage triple‐transgenic Alzheimer's disease model mice by suppressing cardiac hypertrophy and fibrosis

Chih‐Yang Huang, Yi‐Chen Su, Cheng‐You Lu, Ping‐Ling Chiu, more

Environmental Toxicology > 37 > 7 > 1740 - 1749

Some clinical studies have indicated the patients with Alzheimer's disease (AD) display an increased risk of cardiovascular disease (CVD). Here, to examine the relationship between AD and CVDs, we investigated the changes in heart function in triple‐transgenic late‐stage AD model mice (3× Tg‐AD; APPSwe, PS1M146V, and tauP301L). We fed the AD mice folic acid (FA) or folinic acid (FN) and analyzed the...

article

Obstructive sleep apnea and injury events in Taiwanese adults: A retrospective cohort study

Chia‐Ling Lin, Mei‐Chen Su, Chun‐Ping Lin, Chien‐An Sun, more

Journal of Nursing Scholarship > 54 > 1 > 38 - 45

Purpose The aim of this study was to examine the association between obstructive sleep apnea (OSA) diagnosis and diverse types of injuries. Design This population‐based retrospective cohort study compared records from 2000 to 2013 in the Taiwan National Health Insurance Research Database. Methods 3025 patients identified with OSA were compared against the control cohort consisting of 12,100 age‐...

article

Effects of bile acids on the growth performance, lipid metabolism, non‐specific immunity and intestinal microbiota of Pacific white shrimp (Litopenaeus vannamei)

Chen Su, Xintian Liu, Jinbao Li, Mengyu Zhang, more

Aquaculture Nutrition > 27 > 6 > 2029 - 2041

Effects of dietary bile acids on the growth performance, lipid metabolism, non‐specific immunity and intestinal microbiota of Pacific white shrimp (Litopenaeus vannamei) were studied. Five diets were formulated to contain 0, 0.1, 0.2, 0.3 and 0.5 g kg⁻¹ (control, BA1, BA2, BA3 and BA4) of bile acids, respectively. Shrimp (1.09 ± 0.04 g) were assigned randomly to 15 tanks (400 L, three tanks in each...

article

Nuclear transport factor GmNTF2B‐1 enhances soybean drought tolerance by interacting with oxidoreductase GmOXR17 to reduce reactive oxygen species content

Kai Chen, Chen Su, Wensi Tang, Yongbin Zhou, more

The Plant Journal > 107 > 3 > 740 - 759

Drought is a critical abiotic stressor that modulates soybean yield. Drought stress drastically enhances reactive oxygen species (ROS) formation, and maintaining ROS content above a cytostatic level but below a cytotoxic level is essential for normal biology processes in plants. At present, most of the known ROS‐scavenging systems are in the cytoplasm, and the mechanism of ROS regulation in the nucleus...

article

Risk of diabetic macular oedema with sodium‐glucose cotransporter‐2 inhibitors in type 2 diabetes patients: A multi‐institutional cohort study in Taiwan

Yu‐Chen Su, Shih‐Chieh Shao, Edward Chia‐Cheng Lai, Chaw‐Ning Lee, more

Diabetes, Obesity and Metabolism > 23 > 9 > 2067 - 2076

Aims To investigate the risk of diabetic macular oedema (DMO) associated with the use of sodium‐glucose cotransporter‐2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus (T2DM). Materials and Methods We conducted a retrospective cohort study by analysing a large multi‐institutional electronic medical records database in Taiwan. We included adult patients with T2DM without DMO newly receiving...

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INFONA - science communication portal

Search results for: Chen Su

Systematic synthesis and identification of monolignol pathway metabolites

Copper Iodide Hybrid with Unique Cu₃I₃ Trimeric Inorganic Functional Unit and Far‐red/Near‐infrared Emission

Controllable Dopamine Conjugation Boosts Fluorescence, Biocompatibility, and PET Imaging‐Guided Toxicity Assessment of Polycations

Discovery of N,N'‐diarylurea molecules with activity against multidrug‐resistant Staphylococcus aureus

Comparative effectiveness and tolerability of calcitonin gene‐related peptide (CGRP) monoclonal antibodies and onabotulinumtoxinA in chronic migraine: A multicenter, real‐world study in Taiwan

Solitary central nervous system relapse in acute promyelocytic leukemia

Multipathway regulation induced by 4‐(phenylsulfonyl)morpholine derivatives against triple‐negative breast cancer

Activating Tumor‐Selective Liquid Metal Nanomedicine through Galvanic Replacement

Activating Tumor‐Selective Liquid Metal Nanomedicine through Galvanic Replacement (Adv. Mater. 5/2024)

The Impact of Analyst, CEO, and Firm Reputations on Investors in the UK and Japanese Stock Markets

A Behavioural Appraisal of Regulatory Financial Reforms and Implications for Corporate Management

Personalized lifetime prediction of survival and treatment benefit in patients with heart failure with reduced ejection fraction: The LIFE‐HF model

B‐Box proteins BBX28 and BBX29 interplay with PSEUDO‐RESPONSE REGULATORS to fine‐tune circadian clock in Arabidopsis

The velocity field characteristics of high‐viscosity fluids falling film flow down clamped channels

The performance of UK stock recommendation revisions: Does brokerage house reputation matter?

Edible folic acid and medicinal folinic acid produce cardioprotective effects in late‐stage triple‐transgenic Alzheimer's disease model mice by suppressing cardiac hypertrophy and fibrosis

Obstructive sleep apnea and injury events in Taiwanese adults: A retrospective cohort study

Effects of bile acids on the growth performance, lipid metabolism, non‐specific immunity and intestinal microbiota of Pacific white shrimp (Litopenaeus vannamei)

Nuclear transport factor GmNTF2B‐1 enhances soybean drought tolerance by interacting with oxidoreductase GmOXR17 to reduce reactive oxygen species content

Risk of diabetic macular oedema with sodium‐glucose cotransporter‐2 inhibitors in type 2 diabetes patients: A multi‐institutional cohort study in Taiwan

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